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Angiotensin converting enzyme inhibitors-impurity profiling:An overview

Gaurav Sharma, Mukesh Chand

ACE Inhibitors (ACEIs), or inhibitors ofAngiotensin-Converting Enzyme, are a group of pharmaceuticals that are used primarily in treatment of hypertension and congestive heart failure. During the synthesis or manufacturing ofACE inhibitors (API substances), some side productsmay be formed which may be closely related to the product and called as impurities of the drug substances. The chromatographic detection as well as structure elucidation of these impurities is very important. So there is an urgent need of sensitive and accurate analytical methods to detect and isolate these impurities from the API substances. Impurities present in the API substances which are more than 0.1%, should be identified and characterized by using various analytical techniques.