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Analytical study of the physicochemical inerteraction of losartan potassium with triton X 100.

Laila Abdel-Fattah, Amira El-Kosasy, Lobna Abdel-Aziz, Mariam Gaied*

This study is an investigation of the physicochemical interaction of Losartan potassium (LST K), an angiotensin-II receptor (typeAT1) antagonist, with micelles of triton X, a nonionic surfactant. The effect of micelles on the spectral properties of LSTK was monitored on at pH 7.4 and at room temperature. The spectrum of LST K showed gradual and progressive bathochromic and hypochromic shift in presence of increasing concentrations of triton X 100. The binding constant Kb of LST K to triton X 100 micelles was calculated using the differential absorbance at ë = 225 nm& was found to be 4.13 ± 0.35 ×105 mol-1 L. By using pseudo-phase model, the partition coefficient between the bulk water and Triton X 100 micelles, Kx, was calculated fromboth differential absorbance Ä A225, Kx = 2.26 ±0.12 x105mol-1L. The binding of LST K to TritonX 100micelles implied a shift in drug acidity constant (Ä pKa = 0.8) 2013 Trade Science Inc. - INDIA.