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A validated chiral LC method for the enantiomeric separation of naproxcinod

CH.V.Raghunadha Babu, Ashok Sigala, M.Satish Varma, K.Mukkanti, M.V.Suryanarayana

A rapid isocratic chiral HPLC method has been developed for the separation of R-Naproxcinod from S- Naproxcinod. Good resolution viz. Rs > 3 between R- and S- forms ofNaproxcinod was achievedwithChiralcelOD-H (250 x 4.6mm) column using n-hexane, 2-propanol, acetic acid in the ratio of 90:10:0.5 (v/v/v) asmobile phase at ambient temperature. Flowrate was kept as 1.0 mL min-1 and the elution was monitored at 230 nm. This method is capable to detect and quantitate R- Naproxcinod to the levels of 0.14 ìgmL-1.