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A simple and efficient synthesis of calciumchannel blocker Flunarizine

A.Venkat Narsaiah, J.Kranthi Kumar

T-type calciumchannel blocker and anti-ischemic drug 1-[bis (4-fluorophenyl) methyl]-4-cinnamylpiperazine (1) synthesis has been carried out in four steps with an average of 70% yield. This route is very convenient and can be applied for large scale preparation of Flunarizine with high yields.